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Leukemia cutis originating in the extravasation site of i.v. gabexate mesilate infusion
Author(s) -
MIYAKURA Takashi,
YAMAMOTO Toshiyuki,
KURASHIGE Yuta,
NAGAI Ayako,
IGUCHI Tomotaka,
AOTA Yasuo,
TSUBOI Ryoji
Publication year - 2008
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.2007.00407.x
Subject(s) - extravasation , medicine , cutis , leukemia cutis , dermatology , leukemia , pathology
Leukemia cutis is a localized or disseminated skin infiltration by leukemic cells. A 64‐year‐old man was diagnosed with acute myeloid leukemia (AML) complicated by disseminated intravascular coagulation. During the course of treatment with gabexate mesilate, the substance accidentally leaked from the infusion site in his elbow. One month later, a dark red erythema and induration accompanied by severe pain appeared in the area proximal to the gabexate mesilate injection site. The biopsy specimen demonstrated not only inflammation but infiltration of leukemic cells as well. Immunohistochemical staining for intercellular adhesion molecule‐1 and platelet/endothelial cell adhesion molecule‐1 showed strong expression of endothelial cells and leukemic cells. We speculate that the gabexate mesilate might have played a role in the induction of leukemia cutis via adhesion molecules in our case.