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Familial cutaneous collagenoma: New affected family with prepubertal onset
Author(s) -
GUREL Mehmet Salih,
MULAYIM Mehmet Kamil,
OZARDALI Ilyas,
BITIREN Muharrem
Publication year - 2007
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.2007.00314.x
Subject(s) - dermis , septum secundum , medicine , reticular dermis , abdomen , biopsy , skin biopsy , ehlers–danlos syndrome , dermatology , connective tissue , pathology , anatomy , surgery
Two siblings presented with clinical and histopathological findings of familial cutaneous collagenoma which is a rare connective tissue nevus, inherited in an autosomal‐dominant pattern. A 13‐year‐old girl had oval‐round, soft, painless papules, 5–10 mm in size and a total of 9–10 on her abdomen and flanks. Skin biopsy demonstrated dense, coarse collagen fibers in the dermis and a decrease in elastic fibers. Doppler echocardiography indicated an atrioseptal defect of the secundum type. Her 9‐year‐old brother was also examined; four lesions were discovered on his back but he was otherwise normal. Our cases comprise the sixth affected family to be reported in the medical published work and all lesions had appeared prepubertally.