Premium
Psoriasiform and pustular eruption induced by infliximab
Author(s) -
TAKAHASHI Hidetoshi,
HASHIMOTO Yoshio,
ISHIDAYAMAMOTO Akemi,
ASHIDA Toshifumi,
KOHGO Yutaka,
IIZUKA Hajime
Publication year - 2007
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.2007.00312.x
Subject(s) - medicine , infliximab , dermatology , psoriasis , pustulosis , adalimumab , disease , pathology , arthritis , immunology , synovitis
Although antitumor necrosis factor (anti‐TNF)‐α therapy provides beneficial effects on various chronic inflammatory skin diseases including psoriasis, cutaneous side‐effects have also been reported. We describe four patients who showed psoriasiform eruption following anti‐TNF‐α therapy (infliximab) for Crohn's disease. In all patients, Crohn's disease had responded well to infliximab. Three patients developed plaque‐type psoriasiform eruption on the trunk and four extremities, while one patient showed pustular eruption on the palms and soles accompanied with plaque‐type psoriasis. In all these patients, skin lesions subsided with topical application of corticosteroid ointment or psoralen plus ultraviolet A treatment.