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Successful treatment of vulvar lichen sclerosus in a child with low‐concentration topical tacrolimus ointment
Author(s) -
MATSUMOTO Yuka,
YAMAMOTO Toshiyuki,
ISOBE Tamaki,
KUSUNOKI Toshio,
TSUBOI Ryoji
Publication year - 2007
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.2006.00228.x
Subject(s) - lichen sclerosus , dermatology , tacrolimus , medicine , refractory (planetary science) , surgery , biology , astrobiology , transplantation
Lichen sclerosus is a chronic inflammatory skin disorder that has a predilection for the anogenital area. Topical corticosteroid is occasionally effective; however, continuous treatment is often required and recurrence after its stoppage is frequent. Herein, we report a case of vulvar lichen sclerosus in a 5‐year‐old girl, which was refractory to topical corticosteroids. After 14 weeks of treatment with 0.03% tacrolimus ointment once daily, the lesions completely resolved without side‐effects. Of interest, the number of milia within the plaque of lichen sclerosus was reduced in tandem with the improvement of lichen sclerosus. This is the first report of topical low‐concentration tacrolimus treatment showing a dramatic effect in the treatment of childhood vulvar lichen sclerosus.