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Expression patterns of proliferating cell nuclear antigen in trichloroacetic acid peeled skin
Author(s) -
YAMAMOTO Yuki,
UEDE Koji,
YONEI Nozomi,
FURUKAWA Fukumi
Publication year - 2007
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.2006.00225.x
Subject(s) - trichloroacetic acid , proliferating cell nuclear antigen , immunohistochemistry , epidermis (zoology) , antigen , human skin , cell , chemistry , cell growth , biology , pathology , biochemistry , medicine , immunology , anatomy , genetics
This study was designed to investigate whether trichloroacetic acid (TCA) peeling induces cellular proliferation in human skin using an immunohistochemical method. A 40% TCA peel resulted in a greater number of proliferating cell nuclear antigen (PCNA)‐immunopositive cells in the whole epidermis as compared with 60% TCA or phenol peels. This finding suggests that long‐term and frequent TCA peelings of low concentration would require special attention for unexpected cutaneous lesions such as skin tumors.