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Successful treatment with topical tacrolimus in four cases of discoid lupus erythematosus
Author(s) -
SUGANO Masayoshi,
SHINTANI Yoichi,
KOBAYASHI Keiko,
SAKAKIBARA Noriyuki,
ISOMURA Iwao,
MORITA Akimichi
Publication year - 2006
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.2006.00203.x
Subject(s) - tacrolimus , discoid lupus erythematosus , medicine , dermatology , erythema , lupus erythematosus , refractory (planetary science) , adverse effect , cutaneous lupus erythematosus , surgery , immunology , transplantation , physics , astrobiology , antibody
Discoid lupus erythematosus (DLE), a cutaneous form of lupus erythematosus, is characterized as atrophic and scaly erythema and the lesions are often refractory to a wide range of topical or systemic therapies. Herein, we present four cases of DLE that were successfully treated with topical tacrolimus. Tacrolimus ointment (0.1%) was applied to DLE lesions twice daily and the erythematous plaques readily diminished after 4–8 weeks. Adverse effects, such as burning sensation or irritations, were not observed. These results indicate that topical tacrolimus might be an effective and alternative treatment to control DLE.