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Genome‐wide transcriptional profiling in human squamous cell carcinoma of the skin identifies unique tumor‐associated signatures
Author(s) -
KATHPALIA Vinnie P.,
MUSSAK Erich N.,
CHOW Selwyn S.,
LAM Phillip H.,
SKELLEY Nathan,
TIME Michael,
MARKELEWICZ Robert J.,
KANDUC Darja,
LOMAS Lucy,
XIANG Zhaoying,
SINHA Animesh A.
Publication year - 2006
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.2006.00075.x
Subject(s) - biology , phenotype , gene , ptpn11 , pathogenesis , signal transduction , cancer research , gene expression profiling , genetics , computational biology , gene expression , immunology , mutation , kras
The elucidation of specific genetic changes associated with human cancer pathogenesis has focused efforts to relate such changes to the neoplastic phenotype. To further our understanding of the genetic basis of human squamous cell carcinoma (SCC) of the skin, this study used a genome‐wide (12 627 sequences) approach to determine transcriptional signatures in lesional and nonlesional sites from five SCC patients. Several novel genes involving the p53 pathway, anti‐apoptotic pathways, signal transduction, structural loss and DNA replication, including BCL2A1 , MUC4 , PTPN11 (SHP2) and FGF9 , are upregulated in SCC and could warrant further study regarding their role in disease pathogenesis. SCC pathology is likely combinatorial in nature involving the compounded changes from several cellular processes.