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Bucillamine‐Induced Toxic Epidermal Necrolysis and Fixed Drug Eruption
Author(s) -
Izumi Atsuko,
Katsumi Sachiko,
Kobayashi Nobuhiko,
Niizeki Hironori,
Asada Hideo,
Miyagawa Sachiko
Publication year - 2005
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.2005.tb00914.x
Subject(s) - toxic epidermal necrolysis , medicine , provocation test , dermatology , drug eruption , drug , differential diagnosis , pathology , pharmacology , alternative medicine
We report two cases of bucillamine‐induced bullous reactions with keratinocyte necrosis. The first patient, a 27‐year‐old woman, developed toxic epidermal necrolysis (TEN) over her whole body after taking bucillamine 300 mg/day for seven days. The second patient, a 63‐year‐old woman, developed several bullous erythemas on the mucous membranes and legs after taking bucillamine for more than two years. The fixed drug eruptions were diagnosed based on a provocation test in addition to clinical and histopathologic findings. These cases highlight the importance of considering fixed drug eruption as well as TEN in the differential diagnosis of bucillamine‐induced bullous drug eruption.