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Atelocollagen Sponge and Recombinant Basic Fibroblast Growth Factor Combination Therapy for Resistant Wounds with Deep Cavities
Author(s) -
Nakanishi Asako,
Hakamada Arata,
Isoda Kenichi,
Mizutani Hitoshi
Publication year - 2005
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.2005.tb00910.x
Subject(s) - dermis , medicine , fascia , fibroblast , sponge , basic fibroblast growth factor , fibroblast growth factor , negative pressure wound therapy , wound healing , surgery , growth factor , anatomy , pathology , biology , cell culture , botany , receptor , alternative medicine , genetics
Recent advances in bioengineering have introduced materials that enhance wound healing. Even with such new tools, some deep ulcers surrounded by avascular tissues, including bone, tendon, and fascia, are resistant to various therapies and easily form deep cavities with loss of subcutaneous tissue. Atelocollagen sponges have been used as an artificial dermis to cover full‐thickness skin defects. Topical recombinant human basic fibroblast growth factor has been introduced as a growth factor to induce fibroblast proliferation in skin ulcers. We applied these materials in combination in two patients with deep resistant wounds: one with a cavity reaching the mediastinum through a divided sternum and one with deep necrotic wounds caused by electric burns. These wounds did not respond to the topical basic fibroblast growth factor alone. In contrast, the combination therapy closed the wounds rapidly without further surgical treatment. This combination therapy is a potent treatment for resistant wounds with deep cavities.