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A Case of Werner Syndrome with Three Primary Lesions of Malignant Melanoma
Author(s) -
Shibuya Hiromi,
Kato Aiko,
Kai Nobutaka,
Fujiwara Sakuhei,
Goto Makoto
Publication year - 2005
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.2005.tb00835.x
Subject(s) - dacarbazine , melanoma , medicine , werner syndrome , chemotherapy , lesion , vincristine , dermatology , pathology , surgery , cancer research , biology , cyclophosphamide , gene , genetics , helicase , rna
Three primary lesions of malignant melanoma developed in a 44‐year‐old Japanese woman with Werner syndrome. One lesion was on the right large pudental lip and the others in distinct locations on her left sole. After the wide local excision of these tumors, the wound of the large pudental lip was sutured, and the defects on the sole were covered with skin grafts. After one course of chemotherapy consisting of dacarbazine, nimustine, vincristine sulfate and local injection of Interferon β were performed, severe myelosupression occurred and continued for two months. Defective production of WRN protein was confirmed by Western blotting, although the three representative mutations in Japanese patients, mutations 1, 4 and 6, which include over 90% of the Japanese patients, were not detected. We also reviewed 26 cases of malignant melanoma associated with Werner syndrome (WS), including ours.