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Sensitivity and Specificity of Different Diagnostic Criteria for Behçet's Disease in a Group of Turkish Patients
Author(s) -
Dervis Emine,
Geyik Nazmi
Publication year - 2005
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.2005.tb00760.x
Subject(s) - medicine , behcet's disease , sarcoidosis , erythema nodosum , cohort , gastroenterology , dermatology , disease
Because there are no diagnostic laboratory tests or histopathologic findings, the diagnosis of Behçet's disease (BD) is based on clinical criteria. Various diagnostic criteria have been proposed. In this study, we assessed the sensitivity, specificity and the relative value of the Mason & Barnes, Japanese, Hamza, O'Duffy, Cheng & Zhang, Dils̨en and International Study Group (ISG) criteria. Two hundred twenty‐eight patients with Behçet's disease diagnosed according to either O'Duffy's or ISG criteria and 89 control patients with a variety of connective tissue diseases, including sarcoidosis, uveitis, erythema nodosum, and granulomatous intestinal disease, were evaluated. ISG and Hamza criteria showed the highest specificity (100%) in discriminating control subjects from the entire cohort. The highest sensitivity value (100%) was found in the Cheng & Zang criteria, which were found to be the most sensitive but the least specific (74.2%). The Hamza criteria had the highest relative value (sensitivity plus specificity) (198.2). Dils̨en (196.9) and ISG (196.5) criteria also had high relative values. In this study, Hamza, Dils̨en, and ISG criteria performed quite well in diagnosing BD in our country compared to the other criteria sets.