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Simultaneous Onset of Pemphigus Vulgaris in Two Turkish Siblings
Author(s) -
Kavak Ayşe,
Aydoğan İlker,
Gönen Sevim
Publication year - 2005
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.2005.tb00742.x
Subject(s) - pemphigus vulgaris , etiology , azathioprine , medicine , human leukocyte antigen , dermatology , pemphigus , immunology , oral mucosa , disease , antigen , pathology
The etiology of pemphigus vulgaris is still unknown. Reported familial cases are indicators of a genetic aspect of the disease. We report a brother and sister with simultaneous onset of pemphigus vulgaris. The class II antigens, HLA DRB1*04 and DQB1*03 were detected in both patients. The oral mucosa was affected in one them. Elevation of transaminase levels due to azathioprine therapy was observed in these two cases.