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Angiotropic B‐Cell Lymphoma with Telangiectasia, Accompanied by Panniculitic Formation
Author(s) -
Nishiyama Hiromi,
Tanei Ryoji,
Motegi Takashi,
Ohta Masatsugu,
Sawabe Motoji
Publication year - 2004
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.2004.tb00650.x
Subject(s) - medicine , cyclophosphamide , vincristine , prednisolone , chop , lymphoma , chemotherapy , cytarabine , methotrexate , pathology , telangiectasia , dermatology , regimen , gastroenterology
A 67‐year‐old female presented with diffuse edema, generalized telangiectasia, and indurated skin plaques. Histopathological findings of the skin lesion included CD45 + /CD79 + /CD20 + large lymphoma cells that filled the vascular lumina and infiltrated the subcutaneous tissues with panniculitic formations. Three cycles of a CHOP (cyclophosphamide, adriamycin, vincristine, and prednisolone) chemotherapy regimen resolved the skin manifestations. After five cycles of CHOP, however, she developed dementia‐like symptoms. Three cycles of additional intrathecal chemotherapy (methotrexate, cytarabine and prednisolone) did not improve the neurological symptoms.