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Drug‐Induced Hypersensitivity Syndrome Due to Anticonvulsants in a Two‐Year‐Old Boy
Author(s) -
Criado Paulo Ricardo,
Criado Roberta F. J.,
Vasconcellos Cidia,
Pegas Jose Roberto P.,
Cera Patrícia Calil
Publication year - 2004
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.2004.tb00645.x
Subject(s) - phenytoin , medicine , drug , culprit , phenobarbital , drug withdrawal , pathogenesis , epilepsy , immunology , pharmacology , psychiatry , myocardial infarction
Drug‐induced hypersensitivity syndrome (DIHS) usually refers to severe cutaneous drug eruption associated with systemic involvement and potentially fatal outcome. We report a 2‐year‐old Caucasian boy who developed DIHS due to phenytoin and phenobarbital and who showed extensive internal organ involvement. We are alerting that failure to recognize this drug eruption and discontinue the culprit drug may result in increased severity, greater extent of internal organ involvement, and fatal outcome. The recent research about the influence of human herpesvirus 6 co‐infection on the pathogenesis of DIHS is also discussed by the authors in this paper.