Premium
A Case of Refractory Bullous Pemphigoid with Plasmapheresis‐Associated Thrombopenia: Efficacy of Pulsed Intravenous Cyclophosphamide Therapy
Author(s) -
Ogawa Yasushi,
Adachi Ayumi,
Okamoto Miyako,
Hashimoto Takashi,
Tomita Yasushi
Publication year - 2004
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.2004.tb00571.x
Subject(s) - medicine , plasmapheresis , bullous pemphigoid , refractory (planetary science) , cyclophosphamide , azathioprine , methylprednisolone , prednisolone , surgery , dermatology , gastroenterology , chemotherapy , immunology , physics , disease , astrobiology , antibody
We present a 69‐year‐old woman with refractory bullous pemphigoid successfully treated with pulsed intravenous cyclophosphamide therapy. Because various other early treatments including 4,4'‐diaminodiphenylsulphone (DDS), minocycline/nicotinamide, cyclosporin, azathioprine, high‐dose oral prednisolone, and methylprednisolone pulse therapy were either ineffective or intolerable, she was treated with double filtration plasmapheresis, but she responded poorly with the rare complication of severe transient thrombopenia. Finally, she gradually recovered with pulsed intravenous cyclophosphamide therapy.