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Elevated Serum Antimelanocyte Antibody Level in Cerebriform Intradermal Nevus with Vitiligo
Author(s) -
Lee ChihHung,
Yu HsinSu
Publication year - 2004
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.2004.tb00551.x
Subject(s) - vitiligo , scalp , medicine , forehead , dermatology , nevus , pathology , antibody , melanocytic nevus , lesion , intradermal injection , biopsy , melanoma , immunology , anatomy , cancer research
Abstract We describe a rare, but typical case of cerebriform intradermal nevus associated with vitiligo. A 45‐year‐old man had a patch of alopecia over his vertex scalp for 15 years. The microscopic findings of the biopsy revealed a typical deep‐seated intradermal nevus and neuroid differentiation with a few pigments. Three hypopigmented patches developed on the forehead, cheek and index finger five years after the scalp lesion, with loss of both melanocytes and melanins. In addition, no dopa reactions were present. Compared to normal controls, the serum antimelanocyte antibody level in the patient was elevated as determined by cellular enzyme‐linked immunosorbent assay (cellular ELISA). This is the first reported case with elevation of serum antimelanocyte antibody level of cerebriform intradermal nevus with vitiligo. This antibody's presence may be related to the occurrence of the vitiligo in patient with cerebriform intradermal nevus.