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A Case of Anti‐Epiligrin Cicatricial Pemphigoid Associated with Lung Carcinoma and Severe Laryngeal Stenosis: Review of Japanese Cases and Evaluation of Risk for Internal Malignancy
Author(s) -
Matsushima Satoko,
Horiguchi Yuji,
Honda Tetsuya,
Fujii Shinobu,
Okano Takayuki,
Tanabe Masahiro,
Wakayama Toshiaki,
Hashimoto Takashi,
Yancey Kim B.
Publication year - 2004
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.2004.tb00497.x
Subject(s) - medicine , malignancy , lung cancer , carcinoma , dermatology , stenosis , radiology , oncology
Abstract A 68‐year‐old Japanese male with a five‐year‐history of lung carcinoma showed recurrent blisters and erosions on the oral and genital mucosae and the skin. The patient complained of dyspnea due to severe laryngeal stenosis and underwent a tracheostomy. A skin biopsy specimen showed a subepidermal blister and linear deposits of IgG and C3 at the basement membrane zone of the epidermis. Indirect immunofluorescence examination demonstrated circulating IgG anti‐basement membrane zone autoantibodies that reacted to epiligrin on immunoblotting. Based on a diagnosis of anti‐epiligrin cicatricial pemphigoid, he was treated with prednisolone, minocycline hydrochloride and nicotinamide. Although no new skin lesions appeared, he died of lung carcinoma five months after the tracheostomy. A review of reported cases with anti‐epiligrin cicatricial pemphigoid in Japan disclosed that 5 of 16 cases (31.2%) were complicated by internal malignancies.