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A Case of Acute Generalized Exanthematous Pustulosis (AGEP) Possibly Induced by Iohexol
Author(s) -
Atasoy Mustafa,
Erdem Teoman,
Sari Refik Ali
Publication year - 2003
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.2003.tb00466.x
Subject(s) - acute generalized exanthematous pustulosis , medicine , iohexol , dermatology , drug eruption , pustulosis , skin biopsy , spongiosis , trunk , generalized pustular psoriasis , dermis , pathology , biopsy , psoriasis , surgery , drug , pharmacology , ecology , osteomyelitis , osteitis , renal function , biology
Acute generalized exanthematous pustulosis (AGEP) is an uncommon disease manifested as an erythematous pustular eruption. It is usually caused by systemic medication. We describe a patient with acute generalized pustular eruption induced by iohexol. A 52‐year‐old woman developed fever and a generalized pustular eruption on the neck, trunk and extremities three days after taking iohexol. The culture from pustules was sterile. Other systemic and laboratory examinations were normal. A skin biopsy from a lesion on the trunk showed the features of a drug‐induced pustular eruption as a subcorneal blister including neutrophils and eosinophils, mild spongiosis, and a sparse infiltrate at neutrophils and eosinophils in the papillary dermis. The patient had no history of psoriasis. The lesions resolved with systemic corticosteroid therapy within one week and did not relapse. According to our investigation, iohexol‐induced AGEP has not been previously reported. We present an interesting case.