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Severe Palmo‐Plantar Hyperkeratosis in Koebner Epidermolysis Bullosa Simplex
Author(s) -
Shirakata Yuji,
Tamai Katsuto,
Nakaoka Hiroki,
Tokumaru Sho,
Sayama Koji,
Murakami Shinji,
Hashimoto Koji
Publication year - 2003
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.2003.tb00361.x
Subject(s) - epidermolysis bullosa simplex , acanthosis , hyperkeratosis , dermatology , medicine , pathology , skin biopsy , epidermolysis bullosa , basal (medicine) , biopsy , insulin , endocrinology
A 22‐year‐old Japanese woman with Koebner epidermolysis bullosa simplex presented with severe palmo‐plantar hyperkeratosis. Skin biopsy specimens from the palm revealed hyperkeratosis and acanthosis with blistering in the basal cell layer. An electron microscopic study showed cytolysis of basal cells and clumping of tonofilaments forming thick bundles and perinuclear electron‐dense bodies. Hand contractures were released and covered with full thickness autografts or split thickness autografts. The donor site was successfully treated with cultured epidermal autografts.