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Seborrheic Keratosis‐like Lesions in Patients with Epidermodysplasia Verruciformis
Author(s) -
Oliveira Walmar Roncalli,
Neto Cyro Festa,
Rady Peter L.,
Tyring Stephen K.
Publication year - 2003
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.2003.tb00332.x
Subject(s) - epidermodysplasia verruciformis , seborrheic keratosis , malignant transformation , genodermatosis , medicine , actinic keratosis , pathology , dermatology , human papillomavirus , basal cell , biology , biochemistry , gene
Epidermodysplasia verruciformis (EV) is a rare genodermatosis characterized by disseminated infection by human papillomavirus (HPV) and malignant transformation of the lesions in about half of the patients. Two phenotypes of EV have been described according to their propensity to develop malignant tumors. The benign form of EV presents a singular type of lesions comprised of flat warts widely disseminated. The malignant form of EV is highly polymorphic and presents as malignant skin tumors, predominantly basal and squamous cell carcinomas, on sun‐exposed sites. The seborrheic keratosis‐like (SK) lesions in patients of EV have been reported to be associated with the malignant phenotype. In this work, we documented the behavior of SK‐like lesions in nine patients with EV, through clinical observations as well as histological and immunohistochemical findings. We suggest that the HPV infection may promote the occurrence of SK‐like lesions in EV patients. Despite the fact that we did not observe any malignant transformation of these lesions in our series of patients, this possibility was not completely excluded.