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A Novel Liposomal Formulation of Dithranol for Psoriasis: Preliminary Results
Author(s) -
Agarwal Ravindra,
Saraswat Abir,
Kaur Inderjeet,
Katare Om Prakash,
Kumar Bhushan
Publication year - 2002
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.2002.tb00321.x
Subject(s) - dithranol , psoriasis , medicine , tolerability , dermatology , liposome , irritation , adverse effect , pharmacology , chemistry , immunology , biochemistry
We have prepared a novel, aqueous gel‐based, liposome‐entrapped formulation of dithranol. Herein, we report preliminary observations on its efficacy, tolerability, and cosmetic acceptability in treating stable plaque psoriasis. Nineteen plaques of psoriasis in nine adult patients were treated for six weeks in a prospective, open‐label trial. In five patients, there was total clearance of lesions, with more than 50% subsidence in a further two patients. Significantly, there were no reports of lesional or perilesional irritation, and only one patient showed faint brown staining of the skin, which was completely and rapidly reversible. These preliminary results indicate that our liposomal dithranol gel has potential advantages over presently available preparations of dithranol; these may translate into enhanced acceptance of this useful drug by patients and physicians.