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Idiopathic CD4 + T Lymphocytopenia Associated with Disseminated Flat Warts and Alopecia Areata
Author(s) -
Gubinelli Emanuela,
Posteraro Patrizia,
Girolomoni Giampiero
Publication year - 2002
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.2002.tb00197.x
Subject(s) - lymphocytopenia , alopecia areata , medicine , immunodeficiency , dermatology , immunology , epidermodysplasia verruciformis , mycosis fungoides , lymphoma , pathology , immune system , virus , lymphocyte
Idiopathic CD4 + T lymphocytopenia is a very rare condition characterized by persistent depletion of circulating CD4 + T lymphocytes, without evidence of HIV or HTLV infection, or other identifiable causes of immunodeficiency. The syndrome can present with dermatological diseases, including viral, fungal and bacterial infections, as well as Kaposi's sarcoma, epithelial cell malignancies, lymphoma and inflammatory dermatoses. We report the case of a 47‐year‐old woman with idiopathic CD4 + T lymphocytopenia who presented with a 10‐year history of disseminated and refractory flat warts from which human papillomavirus type 3 DNA was identified. The patient also had alopecia areata.