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TCR Gene‐rearranged, Extranodal NK/T‐Cell Lymphoma, Nasal Type, Presenting as Gyrate Patches
Author(s) -
Hwang DongKyu,
Kwon HyeokMan,
Park JinWoo,
Yu HeeJoon,
Park Yong Wook
Publication year - 2002
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.2002.tb00196.x
Subject(s) - mycosis fungoides , lymphoma , pathology , biology , t cell receptor , gene rearrangement , t cell lymphoma , epstein–barr virus , immunohistochemistry , fluorescence in situ hybridization , in situ hybridization , t cell , gene , virus , immunology , gene expression , medicine , immune system , biochemistry , chromosome
In the CD56+ cutaneous nasal‐type NK/T‐cell lymphoma strongly associated with latent EBV infection, subcutaneous or dermal nodules are the most common skin findings, but great morphologic heterogeneity has been noted including papules, infiltrated plaques, and ulcerated tumors, and TCR genes are mostly germline. We describe a case of nasal and nasal‐type NK/T‐cell lymphoma featuring multiple erythematous polycyclic patches on the trunk, which is similar to patch stage mycosis fungoides or other cutaneous T cell lymphoma. Immunohistochemical study of a skin biopsy specimen revealed CD2+, CD3ε+, CD56+, and CD45RO+ expression in the neoplastic cells. In situ hybridization using an anti‐sense Epstein Barr virus early regions probe showed a positive reaction. However, clonal TCR β gene rearrangement was found.