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Elevation of IL‐6 in ATL Patient with a Pathological Fracture
Author(s) -
Anzai Saburo,
Takayasu Susumu,
Fujiwara Sakuhei,
Tateyama Masamichi,
Taira Hirohumi,
Takashita Mitsuhiro
Publication year - 2002
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.2002.tb00195.x
Subject(s) - pathological , medicine , lesion , parathyroid hormone related protein , lymphoma , interleukin 6 , pathology , parathyroid hormone , leukemia , calcium , cytokine
Hypercalcemia and osteolytic bone lesion are important complications in the prognosis of patients with adult T cell leukemia/lymphoma (ATL). We report a 61‐year‐old Japanese woman who died of ATL and had multiple osteolytic lesions and pathological fractures of her extremities. Highly increased serum levels of Interleukin‐6 (IL‐6) and a parathyroid hormone‐related protein (PTHrP) together with a high level of serum calcium observed at the time of fractures suggested their contribution to the formation of the bone lesions.