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Localized Involutional Lipoatrophy: Report of Six Cases
Author(s) -
Yamamoto Toshiyuki,
Yokozeki Hiroo,
Nishioka Kiyoshi
Publication year - 2002
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.2002.tb00194.x
Subject(s) - lipoatrophy , cd68 , medicine , connective tissue , immunohistochemistry , hyaline , pathology , lipodystrophy , dermatology , immunology , human immunodeficiency virus (hiv) , viral load , antiretroviral therapy
We herein report six cases of localized involutional lipoatrophy, who presented with a depressive plaque on the lateralis of the upper arm. All patients were female, and three had previous injections for allergic rhinitis at the affected sites before the development of lipoatrophy. One patient received intramuscular injection at the affected site when she had a cold. Histological examination showed fat lobules composed of small lipocytes in the hyaline connective tissue. Immunohistochemical examination revealed a number of CD68‐positive macrophages in the fat lobules. We consider that localized involutional lipoatrophy is more common than has been reported, and is occasionally induced by local injections.