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Epstein‐Barr Virus‐associated Recurrent Necrotic Papulovesicles with Repeated Bacterial Infections Ending in Sepsis and Death: Consideration of the Relationship between Epstein‐Barr Virus Infection and Immune Defect
Author(s) -
Yoon Tae Young,
Yang Tae Ho,
Hahn Youn Soo,
Huh Joo Ryung,
Kim Youn Soo
Publication year - 2001
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.2001.tb00007.x
Subject(s) - virus , sepsis , epstein–barr virus infection , epstein–barr virus , lymphoma , immunology , scars , immune system , antibody , disease , medicine , biology , virology , pathology
The disease of Epstein‐Barr virus (EBV) ‐associated recurrent necrotic papulovesicles is a distinct clinicopathologic entity different from classic hydroa vacciniforme (HV). A few patients have been reported as atypical HV with systemic involvement, development of lymphoma, and poor prognosis. We describe a patient with recurrent necrotic papulovesicles and multiple varioliform scars in both sun‐exposed and covered areas. In contrast to cases of previously reported atypical HV, our patient suffered from repeated bacterial infections on various sites ending in sepsis and death, but without malignant transformation. EBV was detected in the lymphoid cells from the skin lesions by anti‐latent membrane protein (LMP) antibody and in situ hybridization. We suggest that the repeated bacterial infections in this case raise the possibility of an association of EBV infection with increased susceptibility to bacterial infections.