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A Case of Black Dot Ringworm with a Review of Japanese Cases
Author(s) -
Ooka Shiho,
Kashima Masato,
Kubota Yasuo,
Noguchi Atsushi,
Kawai Shinichi.,
Nakamura Yuka,
Kano Rui,
Watanabe Shinichi,
Hasegawa Atsuhiko,
Mizoguchi Masako
Publication year - 2000
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.2000.tb02249.x
Subject(s) - medicine , dermatology , erythema , prednisolone , veterinary medicine
Black dot ringworm (BDR), caused by Trichophyton violaceum var. glabrum (T. glabrum) , was observed in a 28‐year‐old Japanese female who had been treated with prednisolone (22.5 mg/day) for systemic lupus erythematosus. It was successfully treated with oral terbinafine (125 mg/day) for 12 weeks. The causative fungus was identified by molecular analysis as well as morphological and biochemical examination. The chitin synthase 1 ( CHS1 ) gene cleavage pattern of the clinical isolate with restricted enzyme Hin fI was identical to that of T. violaceum . We reviewed previous reports of BDR to determine the historical trend of this infection in Japan. Since 1974, 93 Japanese cases have been reported. The age distribution was bi‐modal: the higher peak consisted of children (aged 0–15 years), and the lower peak was composed of the elderly (aged 60–75 years). In the elderly group, females were predominant (M: F=1: 22, p<0.001). T. violaceum , including T. glabrum , was identified as the most common causative fungus of BDR (75.3%). Sixty percent of cases showed slight erythema. In 8 families, 16 cases were found to be intrafamilial infections. A history of previous steroid treatment was described in about 40%.