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Topical δ‐Aminolevulinic Acid‐Based Photodynamic Therapy for Japanese Actinic Keratoses
Author(s) -
Itoh Yoshiyasu,
Ninomiya Yoshiharu,
Henta Tetsuro,
Tajima Shingo,
Ishibashi Akira
Publication year - 2000
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.2000.tb02218.x
Subject(s) - photodynamic therapy , dermatology , actinic keratoses , medicine , cure rate , melanin , red light , photochemistry , chemistry , surgery , biology , biochemistry , botany , organic chemistry
Based on the opinion that 5‐aminolevulinic acid‐based photodynamic therapy (ALA‐PDT) may be disadvantageous to Oriental patients with dark skin, including Japanese, because the competing chromophore melanin inhibits the photochemical reaction, we assessed the therapeutic effects when Japanese AK were treated with ALA‐PDT. Fifty‐three lesions in ten patients were followed up for over one year. The cure rates of AK on the face including the neck and on extremities were 81.8% and 55.6%, respectively. The results were approximately the same cure rates as those reported for AK in Caucasian patients. However, a larger number of treatment sessions were required. In the red light range, incoherent light including 630 nm and 670 nm is superior to 630 nm laser light.