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A Case of Classic Kaposi's Sarcoma in a Japanese Man: Detection of Human Herpes Virus 8 (HHV‐8) Infection by Means of Polymerase Chain Reaction and Immunofluorescence Assay
Author(s) -
Yamada Yozo,
Funasaka Yoko,
Nishioka Eri,
Okuno Toshiomi,
Ichihashi Masamitsu
Publication year - 2000
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.2000.tb02189.x
Subject(s) - polymerase chain reaction , virology , lytic cycle , immunofluorescence , virus , antibody , pathogenesis , sarcoma , kaposi's sarcoma , biology , herpesviridae , polymerase , dna , viral disease , medicine , human herpesvirus , gene , immunology , pathology , genetics
The recently discovered human herpes virus 8 (HHV‐8) has been implicated in the pathogenesis of Kaposi's sarcoma (KS). Because classic KS in Japan is rare and the detection of HHV‐8 DNA by polymerase chain reaction (PCR) has heen successful only in limited cases, the frequency and role of HHV‐8 infection in KS in Japan remain unclear. Herein we report a case of classic KS in a Japanese man whose HHV‐8 infection was confirmed by the detection of lesional viral DNA and serum antibodies against lytic antigen.