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Correlation between Deposition of Immuno‐Components and Infiltration Pattern of Polymorphonuclear Leukocytes in the Lesions of Chronic Urticaria
Author(s) -
Sugita Yasushi,
Morita Eishin,
Kawamoto Hiroaki,
Horiuchi Kenji,
Yamada Satoru,
Koro Osamu,
Yamamoto Shoso
Publication year - 2000
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.2000.tb02142.x
Subject(s) - infiltration (hvac) , pathology , medicine , vasculitis , cellular infiltration , edema , population , immunology , inflammation , disease , physics , environmental health , thermodynamics
Urticaria is often associated with perivascular infiltration of leukocytes into the lesions. Although mast cell‐derived chemical mediators are considered to play crucial roles in the infiltration of leukocytes as well as in the dermal edema, other mechanisms for the leukocyte infiltration have not been well defined. This study revealed that approximately 25% of the cases of chronic idiopathic urticaria in whom wheals had continued for more than 12h had deposition of immuno‐components in the lesions, although histological examination of the lesions did not show leukocytoclastic vasculitis. In these lesions with deposition of immuno‐components, both neutrophils and eosinophils had infiltrated at a constant ratio (approximately 2:1), whereas, in the lesions without deposition, a variable population of leukocytes was seen. This result suggests that activation of complements occurs in the lesions of a considerable percentage of patients with chronic idiopathic urticaria and that the complement fragments influence the infiltration patterns of polymorphonuclear leukocytes.