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Juvenile Chronic Myelogenous Leukemia, Neurofibromatosis 1, and Xanthoma
Author(s) -
Jang KyoungAe,
Choi JeeHo,
Sung KyungJeh,
Moon KeeChan,
Koh JaiKyoung,
Im DongJin
Publication year - 1999
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1999.tb03506.x
Subject(s) - xanthoma , neurofibromatosis , chronic myelogenous leukemia , medicine , leukemia , juvenile , dermatology , pathology , immunology , biology , genetics
The triple association of leukemia, xanthomatous skin lesions, and neurofibromatosis 1 (NF) was first described by Royer et al. in 1958. Most of the leukemias were of the juvenile chronic myelogenous type (JCML). We describe a 7‐year‐old male child with xanthoma, neurofibromatosis 1, and juvenile chronic myelogenous leukemia. His mother also had NF1. We suggest that the presence of xanthomas and NF1 in a young child should raise awareness of the possible development of JCML, especially in patients with a family history of NF1.