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A Japanese Case of Dengue Fever with Lymphocytic Vasculitis: Diagnosis by Polymerase Chain Reaction
Author(s) -
Ishikawa Hiroshi,
Okada Shigeru,
Katayama Ichiro,
Mazaki Hironori,
Nagatake Takeshi,
Hasebe Futoshi,
Igarashi Akira
Publication year - 1999
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1999.tb03505.x
Subject(s) - dengue fever , polymerase chain reaction , vasculitis , medicine , virology , pathology , biology , disease , gene , genetics
A 37‐year‐old Japanese male was admitted to Nagasaki University Hospital with abrupt onset of biphasic fever, general malaise and myalgia 9 days after coming back to Japan from Manila. He developed a rubella like erythematous rash 3 days after admission and purpuric eruption one week after admission. A biopsied specimen from the purpura revealed lymphocytic vasculitis with T cell dominance and without immunoglobulin or complement deposition around the blood vessels. RT‐PCR analysis on peripheral blood mononuclear cells using dengue virus specific primers confirmed the diagnosis of type 3 dengue fever. PCR analysis using virus specific primers is a rapid and valuable method for making a correct diagnosis of dengue fever.