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Detection of Human Papilloma Virus Type 58 in a Case of a Perianal Bowen's Disease Coexistent with Adult T‐cell Leukemia
Author(s) -
Uezato Hiroshi,
Hagiwara Keisuke,
Maruno Motoyoshi,
Ramuzi Saeef Taher,
Khaskhely Noor Mohammad,
Oshiro Minoru,
Asato Tsuyoshi,
Nakashima Yasutsugu,
aka Shigeo
Publication year - 1999
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1999.tb03449.x
Subject(s) - bowen's disease , virology , leukemia , human papilloma virus , disease , papilloma , virus , medicine , biology , pathology , basal cell , immunology , genetics , cancer , cervical cancer
A case of Bowen's disease (BD) that appeared in the perianal region of a 65‐year‐old Japanese woman coexistent with chronic adult T cell leukemia (ATL) is described. Histopathological findings revealed that irregularly arranged tumor cells with atypical nuclei throughout the epidermis, which itself disclosed hyperkeratosis, dyskeratotic cells, and clumping cells. Positive staining for HPV antigens was immunohistochemically seen in several nuclei of the tumor cells. Electron microscopic study of the tumor tissue disclosed virus particles of about 50 nm in diameter form the squamous cells. A positive band at 256 bp was obtained by PCR using HPV‐L1 primer. The amplified DNA by L1 primer completely corresponded to that of HPV‐58.