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A Case of Acquired Autoimmune Bullous Disease Associated with IgM Macroglobulinaemia
Author(s) -
Morita Eishin,
Horiuchi Kenji,
Yamamoto Shoso,
Hashimoto Takashi
Publication year - 1999
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1999.tb02070.x
Subject(s) - epidermolysis bullosa acquisita , autoantibody , medicine , immunology , bullous pemphigoid , autoimmune disease , pathology , dermatology , antibody
A variety of autoimmune bullous dermatoses have been reported to develop in association with lymphoproliferative disorders. We report a patient with IgM macroglobulinaemia, who presented with a skin fragility similar to but somewhat milder than that seen in epidermolysis bullosa acquisita. Immunofluorescence detected circulating IgM autoantibodies reacting with the basement membrane zone, which reacted predominantly with dermal side of 1 M NaCl‐split skin. Immunoblotting of the epidermal and dermal extracts with the patient's serum showed no specific reactivity. Further studies are needed to identify the antigenic molecules responsible for the IgM deposition.