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Mast Cell “Densities” in Vascular Proliferations: A Preliminary Study of Pyogenic Granuloma, Portwine Stain, Cavernous Hemangioma, Cherry Angioma, Kaposi's Sarcoma, and Malignant Hemangioendothelioma
Author(s) -
Hagiwara Keisuke,
Khaskhely Noor Mohammad,
Uezato Hiroshi,
aka Shigeo
Publication year - 1999
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1999.tb02052.x
Subject(s) - pyogenic granuloma , capillary hemangioma , medicine , hemangioma , sarcoma , pathology , stain , angioma , staining , vascular disease , lesion , surgery
The “densities” of mast cells (MCs) in six kinds of vascular proliferation, pyogenic granuloma, portwine stain, cavernous hemangioma, cherry angioma, Kaposi's sarcoma, and malignant hemangioendothelioma (MHE), measured per mm 2 were studied using respective specimens prepared with tryptase stain and a personal computer. The average densities of MCs in pyogenic granuloma and MHE were 103.5 ± 25.2/mm 2 (n=10) and 106.3 ± 40.2/mm 2 (n=10) [mean ± standard deviation (SD)]; that in normal skin was 6.85 ± 4.9/mm 2 (n=20) (mean ± SD). is a significant difference [t‐test (p<0.0001) and Wilcoxon‐test (p<0.01)]. The results in portwine stain (n=4), cavernous hemangioma (n=9), cherry angioma (n=4), and Kaposi's sarcoma (n=4) were 68.6 ± 28.9/mm 2 , 105.7 ± 56.9/mm 2 , 85.3 ± 45.6/mm 2 , 82.2 ± 28.4/mm 2 (mean ± SD), respectively, all of which were greater than that in normal skin by a simple comparison. The results of immunofluorescence microscopy were positive with basic fibroblast growth factor staining in the tissues of pyogenic granuloma, Kaposi's sarcoma and MHE. These facts may morphologically indicate a role of MCs in the angiogenesis of these vascular tumors.