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Primary Sjögren's Syndrome Followed by Chronic Myelogenous Leukemia: A Case Report with a Ten Year History
Author(s) -
Minowa Rui,
Miyagawa Sachiko,
Fukumoto Takaya,
Majima Toshimasa,
Shimoyama Taketo,
Fujimura Yoshihiro,
Shirai Toshihiko
Publication year - 1998
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1998.tb02435.x
Subject(s) - busulfan , medicine , anti nuclear antibody , chronic myelogenous leukemia , cyclophosphamide , graft versus host disease , leukemia , transplantation , surgery , antibody , immunology , chemotherapy , autoantibody
We describe a female patient with primary Sjögren's syndrome who subsequently developed chronic myelogenous leukemia. The patient received a bone marrow transplant (BMT) from a genotypically HLA‐identical brother after pre‐transplant preparation with busulfan and cyclophosphamide. Eighteen weeks later, cutaneous and mucosal chronic graft‐versus‐host disease developed, followed by death 11 months after transplantation. Anti‐Ro/SS‐A antibodies disappeared within 6 months post‐BMT, but antinuclear antibodies remained positive through the post‐transplant course.