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Local Cytokine Expression in Steroid‐Modified Tinea Faciei
Author(s) -
Ohta Yukinori,
Saitoh Norimitsu,
Tanuma Hiroyuki,
Fujimura Takao,
Katsuoka Kensei
Publication year - 1998
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1998.tb02415.x
Subject(s) - dermatophyte , cytokine , immunology , hair follicle , dermatomycosis , biology , medicine , microbiology and biotechnology , endocrinology
In tinea faciei , a dermatophyte infection of the face, early stage lesions show erythema with crust and/or vesicles, a condition often misdiagnosed as dermatitis. Steroid application retards the healing in some cases and may induce penetration of the dermatophyte hyphae into hair and hair follicles. In the present study, we examined local immunity mediated by cytokines derived from lesional T lymphocytes in late stage of this disease. Interferon‐gamma (IFN‐γ) and macrophage migration inhibitory factor (MIF) were highly expressed, but neither interleukin‐4 (IL‐4) nor interleukin‐5 (IL‐5) could be detected by RT‐PCR using cryosections. These data suggested that IFN‐γ and MIF may be important in the delayed‐type hypersensitivity (DTH) response against the fungus in the hair follicle in late stages.