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Pretibial Myxedema with Graves' Disease: A Case Report and Review of Japanese Literature
Author(s) -
Ishizawa Toshiyuki,
Sugiki Hiroshi,
Anzai Shinichi,
Kondo Shigeo
Publication year - 1998
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1998.tb02394.x
Subject(s) - myxedema , medicine , graves' disease , dermatology , disease , thyroid
We report a case of pretibial myxedema with Graves' disease in an 18‐year‐old Japanese woman. The physical examination revealed waxy indurated plaques with prominent hair follicle openings and nonpitting edema disseminated on her lower legs. Histology from an edematous lesion revealed that the dermis was markedly thickened with abundant mucin, especially hyaluronic acid, and the collagen fibers in this portion were splitting up into fibrils. We also reviewed 112 cases of pretibial myxedema reported in the Japanese literature.