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A Case of Cutaneous Ki‐1 Positive Anaplastic Large Cell Lymphoma in a Hemodialysed Patient
Author(s) -
Kamada Noriaki,
Kuwahara Takeichirou,
Hatamochi Atsushi,
Shinkai Hiroshi
Publication year - 1998
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1998.tb02378.x
Subject(s) - pathology , anaplastic large cell lymphoma , lymphoma , chromogranin a , immunohistochemistry , medicine , antigen , immunology
A 66‐year‐old woman who suffered from chronic glomerulonephritis had been undergoing hemodialysis for about 10 years. A reddish papule on her waist developed gradually into a nodule (1.9 × 1.4 cm). Histopathological findings showed that the tumor cells had oval to reniform nuclei; multinucleated neoplastic cells and erythrophagocytosis were also present. Immunohistochemical analyses revealed that the membranes of the tumor cells stained for Ber‐H2 (Ki‐1) and epithelial membrane antigen (EMA), Vimentin was partially positive, but keratin, S‐100, chromogranin, leukocyte common antigen (LCA), UCHL‐1, MT‐1, L‐26, MB‐1 and C3D‐1 were all negative. Anti‐human T‐cell leukemia virus‐1 (HTLV‐1) was also negative. No gene rearrangement of the T‐cell receptor β‐, γ‐ and δ‐chain could be detected. From these results, we diagnosed cutaneous Ki‐1 anaplastic large cell lymphoma (ALCL), but the origin could not be determined. The relationship between lymphoma and chronic renal failure and/or hemodialysis was far from clear.