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Drug Eruption (Erythema Multiforme Type) Due to a Digestive Enzyme Drug
Author(s) -
Miyoshi Hayao,
Kanzaki Tamotsu
Publication year - 1998
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1998.tb02341.x
Subject(s) - drug eruption , erythema multiforme , drug , ingestion , erythema , medicine , dermatology , digestive tract , gastroenterology , pharmacology
An 84‐year‐old Japanese male had pruritic indurated erythema on his upper limb and left lower abdomen, which had developed abruptly two months before visiting our hospital. Hematological examination showed eosinophilia, 550/mm 3 . Histopathological findings were suggestive of erythema multiforme in response to a drug. By means of patch tests and a p.o. challenge test, Aczym ® , a digestive enzyme drug, was shown to be the cause of his condition. Further study revealed that the specific ingredients involved were pancreatin and Taka‐diastase. An eruption resulting from ingestion of a digestive enzyme drug has not previously been reported.