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Scaling Lichenoid Eruptions and Sjögren‐like Syndrome: Manifestations of Nonfatal Postoperative Transfusion‐Associated Graft‐versus‐Host Disease?
Author(s) -
Tanei Ryoji,
Yamamoto Tatsuo,
Yokono Hideki,
Motoori Tadashi
Publication year - 1997
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1997.tb02832.x
Subject(s) - medicine , sicca syndrome , clearance , lesion , skin biopsy , dermatology , biopsy , graft versus host disease , surgery , disease , pathology , urology
We report a case of an 81‐year‐old woman in whom lichenoid eruptions and Sjögren‐like sicca syndrome developed 45 days after cholecystectomy. During surgery, one unit (130 ml) of unirradiated packed red blood cells from a male donor was transfused. The lichenoid eruptions cleared up with exfoliation; however, sicca symptoms remained during the follow‐up period of four years. Histological examinations of both skin and lip biopsy specimens were in agreement with those of graft‐versus‐host disease (GVHD). A Y‐chromosomal body was identified in the lymphocytes in the skin lesion by staining with quinacrine dihydrochloride and in the lip lesion by a method with in situ hybridization. The findings suggest that this case demonstrated the manifestations of non‐fatal transfusion‐associated GVHD.