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Folliculosebaceous Cystic Hamartoma with a Neural Component: An Immunohistochemical Study
Author(s) -
Toyoda Masahiko,
Morohashi Masaaki
Publication year - 1997
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1997.tb02819.x
Subject(s) - hamartoma , vasoactive intestinal peptide , immunohistochemistry , neuropeptide , pathology , calcitonin gene related peptide , calcitonin , substance p , biology , gene product , anatomy , medicine , endocrinology , gene , gene expression , receptor , biochemistry
We present a case of follicular cystic hamartoma, a distinctive cutaneous malformation characterized by marked overgrowth of folliculosebaceous units accompanied by appreciable mesenchymal alterations, including fibroplasia, increased vascular components, and numerous adipocytes. A conspicuous feature of our case is an aggregation of thick trespassing nerve bundles in the deep portion of the neoplasm. An immunohistochemical study revealed the nerve bundles were immunoreactive for the general neuronal marker protein gene product 9.5. The nerves, however, stained negatively with antibodies against neuropeptides such as calcitonin gene‐related peptide, substance P, vasoactive intestinal polypeptide, and neuropeptide Y, all of which are known to be contained in normal cutaneous nerves. The presence of these aberrant nerve bundles devoid of the normal expression of neuropeptides supports the concept that folliculosebaceous cystic hamartoma is a true, tumor‐like malformation characterized by abnormal overgrowth of normal components of the skin.