Premium
Acanthosis Nigricans Associated with Hepatolenticular Degeneration
Author(s) -
Thaipisuttikul Yupin
Publication year - 1997
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1997.tb02810.x
Subject(s) - acanthosis nigricans , medicine , degeneration (medical) , acanthosis , dermatology , groin , dyskeratosis , presentation (obstetrics) , hyperkeratosis , pathology , surgery , obesity , insulin resistance
Acanthosis nigricans and hepatolenticular degeneration (Wilson's disease) developed simultaneously in a 16‐year‐old boy. The diagnosis of Wilson's disease was based on the clinical presentation, including Kayser‐Fleischer ring, hypoceruloplasminemia, hypocupremia, and hypercupriuria. His skin lesions were characterized by thick, dark brown, verrucous plaques on the dorsa of both feet, the neck, axillae, and groin. The histological findings were compatible with acanthosis nigricans. Six months after treatment with D‐penicillamine, two grams per day, his skin lesions and neurological symptoms were much improved and no complications were observed.