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Primary Cutaneous Langerhans Cell Histiocytosis Treated with Photochemotherapy
Author(s) -
Kwon Oh Sang,
Cho Kwang Hyun,
Song Kye Yong
Publication year - 1997
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1997.tb02740.x
Subject(s) - histiocyte , asymptomatic , langerhans cell histiocytosis , puva therapy , medicine , langerhans cell , dermatology , pathology , histiocytosis , biopsy , skin biopsy , epidermis (zoology) , antigen , immunology , psoriasis , anatomy , disease
A 23‐year‐old man with Langerhans cell histiocytosis presented with asymptomatic, purplish, slightly scaly, confluent papules of one year's duration. Histological studies of biopsy specimens revealed a dense infiltrate of histiocytic mononuclear cells beneath the epidermis; these cells reacted strongly with anti‐S‐100 antibodies. Extensive investigations failed to detect systemic involvement. He was treated with repeated oral 8‐methoxypsoralen (8‐MOP) plus ultraviolet A (PUVA) therapy three times a week for two months and then once or twice with maintenance phototherapy. The lesions did not recur during the four‐month follow‐up period.