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Asymptomatic Primary Sjögren's Syndrome in a Patient with Penicillin Drug Eruption
Author(s) -
Takahashi Hiroyuki
Publication year - 1997
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1997.tb02739.x
Subject(s) - medicine , asymptomatic , dermatology , rheumatoid factor , penicillin , drug eruption , serology , skin biopsy , drug , antibody , biopsy , immunology , surgery , pathology , antibiotics , biology , psychiatry , microbiology and biotechnology
Abstract A 20‐year‐old woman visited our clinic because of acral numbness and skin eruptions after administration of oral penicillin. Serological tests revealed an increase of immunoglobulins (G & M), positive rheumatoid factor, anti‐nuclear factor, anti‐SSA and ‐SSB antibodies. Ophthalmologic and otolaryngological studies were consistent with those of Sjögren's syndrome. However, a skin biopsy specimen failed to show any specific changes for Sjögren's syndrome and the diagnosis of penicillin drug eruption was considered to be more preferable. We briefly discussed the coexistence of a drug allergy and asymptomatic connective tissue disease.