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Toxic Epidermal Necrolysis Possibly Linked to Hyperacute Graft‐versus‐Host Disease after Allogeneic Bone Marrow Transplantation
Author(s) -
Takeda Hikaru,
Mitsuhashi Yoshihiko,
Kondo Shigeo,
Kato Yuichi,
Tajima Katsufumi
Publication year - 1997
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1997.tb02308.x
Subject(s) - toxic epidermal necrolysis , medicine , bone marrow transplantation , graft versus host disease , disease , bone marrow , pathogenesis , transplantation , adverse effect , drug reaction , drug , dermatology , immunology , surgery , pathology , pharmacology
Toxic epidermal necrolysis (TEN) is a severe blistering skin disease of high mortality. TEN may occur after bone marrow transplantation (BMT). In such cases, TEN have been attributed to graft‐versus‐host disease (GVHD) or an adverse drug reaction. It is very difficult to distinguish the causes of TEN after BMT. We report a 21‐year‐old Japanese man who developed TEN eight days after BMT, evaluate the differential diagnosis of hyperacute GVHD and an adverse drug reaction, and deduce that hyperacute GVHD was the more likely pathogenesis of TEN in this patient.