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Lupus Panniculitis Treated by a Combination Therapy of Hydroxychloroquine and Quinacrine
Author(s) -
Chung HaeShin,
Hann SeungKyung
Publication year - 1997
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1997.tb02294.x
Subject(s) - hydroxychloroquine , medicine , panniculitis , asymptomatic , histiocyte , pathology , lupus erythematosus , dermatology , erythema , systemic lupus erythematosus , immunology , disease , covid-19 , infectious disease (medical specialty) , antibody
Lupus erythematosus panniculitis (LEP) is an unusual clinical variant of lupus erythematosus (LE) in which the cutaneous inflammatory reaction occurs primarily in the deeper corium. The common clinical features of LEP includes asymptomatic, firm, sharply defined nodules. The histologic findings are characterized by nonspecific panniculitis composed of lymphoid cells, plasma cells, and histiocytes with varying degrees of necrobiotic changes with fibrinoid deposits. In our case, a 24‐year‐old male patient visited our clinic with non‐tender, hard, plaquelike lesions and overlying erythema on the left zygomatic, nasal, and submandibular area. Histopathologic and direct immunofluorescent findings of the lesion were compatible with LEP. His skin lesions waxed and waned with systemic steroid or hydroxychloroquine therapy. He has responded well to a combination therapy of hydroxychloroquine and quinacrine.