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Humoral Hypercalcemia of Malignancy with Elevated Plasma PTHrP, TNFα and IL‐6 in Cutaneous Squamous Cell Carcinoma
Author(s) -
Mori Hiroki,
Aoki Kazuhiro,
Katayama Ichirou,
Nishioka Kiyoshi,
Umeda Tadashi
Publication year - 1996
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1996.tb04055.x
Subject(s) - malignancy , parathyroid hormone related protein , medicine , cytokine , tumor necrosis factor alpha , carcinoma , pathology , interleukin 6 , basal cell , parathyroid hormone , calcium
A case of humoral hypercalcemia of malignancy in cutaneous squamous cell carcinoma is reported. An 82‐year‐old male underwent surgery for cutaneous squamous cell carcinoma (SCC) of the left hand in 1992. He subsequently developed clouding of consciousness with remarkable hypercalcemia, a high parathyroid hormone related protein (PTHrP) level, and elevated plasma cytokine levels [tumor necrosis factor α (TNFα), interleukin‐6 (IL‐6)]. Diagnosis of humoral hypercalcemia of malignancy (HHM) was made on the basis of these findings. He died of renal insufficiency due to this hypercalcemia in spite of several replacement therapies and chemotherapies. The PTHrP might have derived from the SCC and have been responsible for the HHM in conjunction with IL‐6 and TNFα.