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Evaluation of Sialyl Lewis x Antigen in the Skin and the Sera of Patients with Psoriasis Vulgaris
Author(s) -
Ohta Keiji,
Furukawa Fukumi,
Fujita Mayumi,
KashiharaSawami Mari,
Horiguchi Yuji,
Ueda Masamichi,
Kurokawa Shigeko,
Takigawa Masahiro,
Imamura Sadao
Publication year - 1996
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1996.tb03977.x
Subject(s) - psoriasis , epidermis (zoology) , antigen , birbeck granules , monoclonal antibody , chemistry , sialyl lewis x , antibody , pathology , immunology , microbiology and biotechnology , medicine , biology , langerhans cell , anatomy , inflammation , selectin
The roles of sialyl‐Lewis x antigen were evaluated in the pathogenesis of psoriasis. Sialyl‐Lewis x expression was investigated immunohistochemically in the epidermis of normal human skin and erythematous lesional skin of psoriasis vulgaris by avidin‐biotin‐peroxidase complex procedures. A few sialyl‐Lewis x positive dendritic cells were detected in the epidermis of normal human skin. In 7 out of 9 cases of psoriasis vulgaris, the number of sialyl‐Lewis x ‐positive epidermal dendritic cells increased in the erythematous lesion over the adjacent normal skin; there were no marked changes in the numbers of CD1a‐positive cells in the epidermis between the two skin types. In the double immunofluorescence studies, more than half of the sialyl‐Lewis x ‐positive epidermal cells in psoriatic erythema were stained with a monoclonal Lag antibody that specifically reacts with Birbeck granules and related structures of human Langerhans cells. Furthermore, we determined the changes in serum levels of sialyl‐Lewis x antigens in patients with psoriasis. Although levels in the sera were not significantly elevated over those of controls, the increases correlated with the degree of disease activity. These findings suggest that sialyl‐Lewis x antigen is possibly involved in the development of psoriasis.