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Keratinocyte‐derived Cytokines and UVB‐Induced Immunosuppression
Author(s) -
Kondo Seiji,
Sauder Daniel N.
Publication year - 1995
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1995.tb03939.x
Subject(s) - immunosuppression , keratinocyte , immunology , biology , medicine , cell culture , genetics
Ultraviolet radiation (UVB) in sunlight is known to have multiple effects on the immune system. Evidence suggests that UVB‐induced immunosuppression is mediated in part by immunosuppressive and immunoregulatory cytokines. Our studies have utilized gene‐targeted mutant mice to determine key molecular requirements essential for the development of UVB‐induced immunosuppression. Preliminary results from our laboratory suggest that TNF‐ α plays a regulatory role in contact hypersensitivity, but is not a crucial factor for UVB‐induced immunosuppression, and that multiple factors are involved in the induction of UVB mediated immunosuppression.